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25i-NBOMe powder (Cimbi-36 and 2C-B-NBOMe) is novel synthetic psychedelic substance of the phenethylamine chemical class. It produces an array of visually-dominant and stimulating psychedelic effects when administered.
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The name 25B-NBOMe, which short-hand for 2C-B-NBOMe, is a derivative of the phenethylamine psychedelic 2C-B. It acts as a potent partial agonist for the 5-HT2A receptor. Clinical trials with an evaluation dose for safety consideration to humans of only 1 microgram. Such a dose to be only 1/300th the dose is to be hallucinogenic to humans and that recreational use would greatly exceed doses.
Anecdotal reports from users suggest 25B-NBOMe to be an active hallucinogen at a dose of as little as 250–500 µg. Its makes it a similar potency to other phenethylamine derived hallucinogens such as Bromo-DragonFLY. It is worth noting that compounds of the NBOMe class are not orally active. Therefore, intake should be by placing the substance into one’s mouth and allowing it to slowly absorb over a period of 15-30 minutes.
In addition, with its highly sensitive dose-response and unpredictable effects, many reports also suggest that this substance may be overly difficult to use safely. Therefore, it is highly advised to approach this poorly understood, precaution and harm reduction practices if choosing to use it. 25i-NBOMe powder legally
25B-NBOMe or 2C-B-NBOMe is a serotonergic N-benzyl derivative. It substitutes phenethylamine psychedelic as 2C-B. 25B-NBOMe substitutes phenethylamine with methoxy groups CH3O- attached to carbons R2 and R5 as well as a bromine atom attached to carbon R4. It differs from 2C-B structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group. 25B-NBOMe shares this 2-methoxybenzyl substitution with other chemicals of the NBOMe family.
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